Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.50 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.45 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.45 |
| ▸ | ITGAL | P20701 | 1/20 | 0.45 |
| ▸ | EP300 | Q09472 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | SMO | Q99835 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692248 | 0.91 | ALOX5 (0.47) | ALOX5ITGB2ICAM1ITGALCES2 | |
| SCHEMBL4693030 | 0.86 | GAA (0.39) | ALOX5ITGB2ICAM1ITGALEP300 | |
| SCHEMBL4690051 | 0.83 | ALOX5 (0.46) | ALOX5ITGB2ICAM1ITGALCES2 | |
| SCHEMBL4687618 | 0.81 | ITGB2 (0.41) | ALOX5ITGB2ICAM1ITGALEP300 | |
| SCHEMBL29158505 | 0.81 | ALDH1A1 (0.55) | ALOX5CES2GAACYP1A2CYP3A4 | |
| SCHEMBL9719342 | 0.80 | ALOX5 (0.47) | ALOX5CYP1A2CYP3A4CYP2C19MEN1 | |
| SCHEMBL4688597 | 0.78 | ALOX5 (0.48) | ALOX5ITGB2ICAM1ITGALCES2 | |
| SCHEMBL4599210 | 0.78 | ALDH1A1 (0.48) | ALOX5CES2GAACYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL8805740 | 0.77 | MAPK1 (0.48) | ALOX5CES2GAACYP1A2CYP3A4 | |
| SCHEMBL9719340 | 0.75 | GSK3B (0.51) | ALOX5CES2GAACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399155-B1 | SMALL MOLECULES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASE | BOEHRINGER INGELHEIM PHARMA (US) | 2008-05-28 | — | — | EP | claimed |
| US-6414153-B1 | TREATMENT OF INFLAMMATORY OR IMMUNE CELL-MEDIATED DISEASE OR CONDITION | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2002-07-02 | — | — | US | claimed |
| EP-1399155-B1 | SMALL MOLECULES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASE | BOEHRINGER INGELHEIM PHARMA (US) | 2008-05-28 | — | — | EP | disclosed |
| US-6414153-B1 | TREATMENT OF INFLAMMATORY OR IMMUNE CELL-MEDIATED DISEASE OR CONDITION | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2002-07-02 | — | — | US | disclosed |