Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2006521 | 0.94 | PKM (0.49) | PKMLMNAHTTSMN1; SMN2TSHR | |
| SCHEMBL2007303 | 0.94 | PKM (0.57) | PKMLMNAHTTSMN1; SMN2TSHR | |
| SCHEMBL2007289 | 0.92 | MEN1 (0.47) | PKMLMNAHTTSMN1; SMN2NPSR1 | |
| SCHEMBL2006592 | 0.92 | MEN1 (0.47) | PKMLMNAHTTSMN1; SMN2NPSR1 | |
| SCHEMBL3058037 | 0.83 | MAPT (0.46) | PKMLMNAHTTSMN1; SMN2TSHR | |
| SCHEMBL2008626 | 0.83 | ALDH1A1 (0.60) | PKMLMNAHTTSMN1; SMN2USP2 | |
| SCHEMBL3139507 | 0.83 | CHRM4 (0.47) | PKMLMNAHTTSMN1; SMN2NPSR1 | |
| SCHEMBL2012893 | 0.82 | KMT2A (0.53) | PKMLMNAHTTSMN1; SMN2USP2 | |
| SCHEMBL2006326 | 0.82 | ALDH1A1 (0.50) | PKMLMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2010721 | 0.82 | PKM (0.51) | PKMLMNAHTTSMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981504-A2 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES | NV Remynd (BE) | 2008-10-22 | — | — | EP | claimed |
| WO-2007090617-A2 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES | NV REMYND (BE) | 2007-08-16 | — | — | WO | claimed |