Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | GLS | O94925 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | PAM | P19021 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3789475 | 0.86 | TDP1 (0.54) | TDP1L3MBTL1ALDH1A1TSHRMAPK1 | |
| SCHEMBL27759597 | 0.85 | L3MBTL1 (0.50) | TDP1L3MBTL1ALDH1A1TSHRMAPK1 | |
| SCHEMBL456516 | 0.83 | ALDH1A1 (0.59) | TDP1L3MBTL1ALDH1A1TSHRMAPK1 | |
| Hydrochloric Acid SCHEMBL27576461 | 0.82 | L3MBTL1 (0.58) | TDP1L3MBTL1ALDH1A1TSHRMAPK1 | |
| SCHEMBL27672935 | 0.82 | ALDH1A1 (0.58) | TDP1L3MBTL1ALDH1A1TSHRMAPK1 | |
| SCHEMBL27592314 | 0.80 | ALDH1A1 (0.66) | TDP1L3MBTL1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL27484985 | 0.80 | ALDH1A1 (0.56) | TDP1L3MBTL1ALDH1A1TSHRMAPK1 | |
| SCHEMBL750022 | 0.80 | TSHR (0.51) | TDP1L3MBTL1ALDH1A1TSHRMAPK1 | |
| SCHEMBL290979 | 0.80 | SMN1; SMN2 (0.48) | TDP1L3MBTL1ALDH1A1TSHRMAPK1 | |
| SCHEMBL7357013 | 0.79 | TDP1 (0.58) | TDP1L3MBTL1ALDH1A1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989186-A1 | HYDANTOIN BASED KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-11-12 | — | — | EP | disclosed |
| WO-2008101840-A1 | COMBINATION OF ERLOTINIB AND MEK-INHIBITORS FOR INHIBITING PROLIFERATION OF TUMOR CELLS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-08-28 | — | — | WO | disclosed |
| WO-2007096259-A1 | HYDANTOIN BASED KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-30 | — | — | WO | disclosed |