Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 4/20 | 0.40 |
| ▸ | BACE1 | P56817 | 8/20 | 0.37 |
| ▸ | CTSD | P07339 | 3/20 | 0.37 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.35 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.35 |
| ▸ | ANPEP | P15144 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL175480 | 0.85 | LMNA (0.48) | BCHEBACE1CTSDBACE2F2 | |
| Hydrochloric Acid SCHEMBL5219543 | 0.84 | LMNA (0.47) | BCHEBACE1CTSDBACE2F2 | |
| SCHEMBL5218712 | 0.81 | OPRM1 (0.47) | BCHEBACE1CTSDBACE2F2 | |
| SCHEMBL7951036 | 0.77 | BCHE (0.61) | BCHEBACE1F2LMNACSNK1E | |
| SCHEMBL3353939 | 0.77 | BCHE (0.61) | BCHEBACE1F2LMNACSNK1E | |
| SCHEMBL496172 | 0.77 | BCHE (0.61) | BCHEBACE1F2LMNACSNK1E | |
| SCHEMBL2605624 | 0.77 | BCHE (0.61) | BCHEBACE1F2LMNACSNK1E | |
| SCHEMBL5216600 | 0.76 | BACE1 (0.49) | BCHEBACE1F2LMNACSNK1E | |
| Hydrochloric Acid SCHEMBL497150 | 0.75 | BCHE (0.60) | BCHEBACE1F2LMNACSNK1E | |
| Hydrochloric Acid SCHEMBL5225060 | 0.75 | BCHE (0.60) | BCHEBACE1F2LMNACSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692143-B1 | TRICYCLIC INDOLE HYDROXYETHYLAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2008-11-12 | — | — | EP | disclosed |