Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 3/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 3/20 | 0.41 |
| ▸ | HTR1B | P28222 | 3/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1196742 | 0.88 | KDM4E (0.55) | MTNR1AHTR1AHTR7HTR6KDM4E | |
| SCHEMBL4689087 | 0.88 | ICMT (0.48) | MTNR1AHTR1AKDM4EHTR1DHTR1B | |
| SCHEMBL1196741 | 0.88 | KDM4E (0.55) | MTNR1AHTR1AHTR7HTR6KDM4E | |
| SCHEMBL4689483 | 0.84 | HTR1B (0.46) | MTNR1AHTR1AKDM4EHTR1DHTR1B | |
| SCHEMBL4686398 | 0.83 | TSHR (0.50) | MTNR1ATRPM8MTNR1B | |
| SCHEMBL4687515 | 0.83 | GABRA1 (0.52) | MTNR1ATRPM8MTNR1B | |
| SCHEMBL3949134 | 0.82 | TRPV1 (0.44) | TRPV1MTNR1AHTR1AHTR7HTR6 | |
| SCHEMBL3951177 | 0.80 | TRPV1 (0.54) | TRPV1MTNR1AHTR1AKDM4EHTR1D | |
| SCHEMBL3951173 | 0.80 | TRPV1 (0.54) | TRPV1MTNR1AHTR1AKDM4EHTR1D | |
| SCHEMBL3223154 | 0.78 | TRPV1 (0.55) | TRPV1MTNR1AHTR1AHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996592-A1 | INDOLOPYRIDINES AS EG5 KINESIN MODULATORS | Nycomed GmbH (DE) | 2008-12-03 | — | — | EP | disclosed |
| EP-1994033-A1 | INDOLOPYRIDINES AS EG5 KINESIN MODULATORS | 4SC AG (DE) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007096393-A1 | INDOLOPYRIDINES AS EG5 KINESIN MODULATORS | 4SC AG (DE) | 2007-08-30 | — | — | WO | disclosed |
| WO-2007096395-A1 | INDOLOPYRIDINES AS EG5 KINESIN MODULATORS | 4SC AG (DE) | 2007-08-30 | — | — | WO | disclosed |