Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.52 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.52 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.52 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4686398 | 0.86 | TSHR (0.50) | MTNR1AMTNR1BGPR84HTR2ATRPM8 | |
| SCHEMBL4689087 | 0.85 | ICMT (0.48) | MTNR1AMTNR1BHTR2ATRPM8 | |
| SCHEMBL1196741 | 0.85 | KDM4E (0.55) | MTNR1AMTNR1BGPR84HTR2ATRPM8 | |
| SCHEMBL1196742 | 0.85 | KDM4E (0.55) | MTNR1AMTNR1BGPR84HTR2ATRPM8 | |
| SCHEMBL4689697 | 0.83 | TRPV1 (0.47) | MTNR1AMTNR1BTRPM8 | |
| SCHEMBL4689483 | 0.81 | HTR1B (0.46) | MTNR1AMTNR1BHTR2ATRPM8 | |
| SCHEMBL4689070 | 0.81 | GABRA1 (0.48) | GABRA1GABRB1GABRA3GABRB2MTNR1A | |
| SCHEMBL30419995 | 0.77 | PKM (0.67) | GABRA1GABRB1GABRA3GABRB2MTNR1A | |
| SCHEMBL3703101 | 0.77 | PKM (0.67) | GABRA1GABRB1GABRA3GABRB2MTNR1A | |
| SCHEMBL5263791 | 0.75 | SCN9A (0.64) | GABRA1GABRB1GABRA3GABRB2MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996592-A1 | INDOLOPYRIDINES AS EG5 KINESIN MODULATORS | Nycomed GmbH (DE) | 2008-12-03 | — | — | EP | disclosed |
| EP-1994033-A1 | INDOLOPYRIDINES AS EG5 KINESIN MODULATORS | 4SC AG (DE) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007096393-A1 | INDOLOPYRIDINES AS EG5 KINESIN MODULATORS | 4SC AG (DE) | 2007-08-30 | — | — | WO | disclosed |
| WO-2007096395-A1 | INDOLOPYRIDINES AS EG5 KINESIN MODULATORS | 4SC AG (DE) | 2007-08-30 | — | — | WO | disclosed |