Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | QPCT | Q16769 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4687567 | 0.77 | LMNA (0.56) | SMN1; SMN2TP53MEN1KMT2AGAA | |
| SCHEMBL6205797 | 0.75 | GAA (0.45) | SMN1; SMN2TP53MEN1KMT2AGAA | |
| SCHEMBL6207367 | 0.73 | LMNA (0.47) | SMN1; SMN2TP53MEN1KMT2AGAA | |
| SCHEMBL4836759 | 0.72 | MAPK14 (0.54) | MAPK8SMN1; SMN2TP53MAPK14GAA | |
| SCHEMBL4692835 | 0.71 | MAPT (0.45) | SMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL22165488 | 0.70 | SMN1; SMN2 (0.62) | SMN1; SMN2TP53MEN1KMT2AGAA | |
| SCHEMBL4764854 | 0.68 | CCKAR (0.45) | — | |
| SCHEMBL4764898 | 0.68 | ESR1 (0.42) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL29542273 | 0.67 | SMN1; SMN2 (0.56) | SMN1; SMN2TP53MEN1KMT2AGAA | |
| SCHEMBL22178978 | 0.67 | SMN1; SMN2 (0.56) | SMN1; SMN2TP53MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556384-B1 | PYRIMIDO COMPOUNDS HAVING ANTIPROLIFERATIVE ACTIVITY | HOFFMANN LA ROCHE (CH) | 2008-02-20 | — | — | EP | disclosed |
| EP-1556384-A2 | PYRIMIDO COMPOUNDS HAVING ANTIPROLIFERATIVE ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004018472-A2 | PYRIMIDO COMPOUNDS HAVING ANTIPROLIFERATIVE ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2004-03-04 | — | — | WO | disclosed |