Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KLK7 | P49862 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4687567 | 0.88 | LMNA (0.56) | LMNAPOLBSMN1; SMN2CNR1TP53 | |
| SCHEMBL6202984 | 0.74 | MAPT (0.42) | SMN1; SMN2KMT2AMEN1GAAHTT | |
| SCHEMBL4689918 | 0.73 | PTGIR (0.45) | LMNASMN1; SMN2TP53KMT2AMEN1 | |
| SCHEMBL6205797 | 0.72 | GAA (0.45) | SMN1; SMN2TP53KMT2AMEN1GAA | |
| SCHEMBL5795287 | 0.72 | SMN1; SMN2 (0.38) | LMNAPOLBSMN1; SMN2TP53KMT2A | |
| SCHEMBL6205153 | 0.71 | SMN1; SMN2 (0.35) | LMNASMN1; SMN2TP53KMT2AGAA | |
| SCHEMBL4764854 | 0.70 | CCKAR (0.45) | POLB | |
| SCHEMBL5831973 | 0.70 | SMN1; SMN2 (0.39) | LMNAPOLBSMN1; SMN2TP53KMT2A | |
| SCHEMBL5831974 | 0.70 | SMN1; SMN2 (0.39) | LMNAPOLBSMN1; SMN2TP53KMT2A | |
| SCHEMBL4764898 | 0.69 | ESR1 (0.42) | SMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1560832-A1 | PYRIMIDO 4,5-D PYRIMIDINE DERIVATIVES WITH ANTICANCER ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2005-08-10 | — | — | EP | disclosed |
| WO-2004041822-A1 | PYRIMIDO[4,5-D]PYRIMIDINE DERIVATIVES WITH ANTICANCER ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2004-05-21 | — | — | WO | disclosed |