Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | RNF4 | P78317 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | PLAAT3 | P53816 | 2/20 | 0.43 |
| ▸ | PLAAT5 | Q96KN8 | 2/20 | 0.43 |
| ▸ | PLAAT2 | Q9NWW9 | 2/20 | 0.43 |
| ▸ | PLAAT4 | Q9UL19 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6205153 | 0.76 | SMN1; SMN2 (0.35) | GAASMN1; SMN2RNF4TP53ALDH1A1 | |
| SCHEMBL4687567 | 0.76 | LMNA (0.56) | GAASMN1; SMN2RNF4TP53KMT2A | |
| SCHEMBL4689918 | 0.75 | PTGIR (0.45) | GAASMN1; SMN2TP53KMT2AMEN1 | |
| SCHEMBL6207367 | 0.72 | LMNA (0.47) | GAASMN1; SMN2TP53KMT2AMEN1 | |
| SCHEMBL16232251 | 0.71 | KMT2A (0.61) | GAASMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL5831974 | 0.68 | SMN1; SMN2 (0.39) | GAASMN1; SMN2RNF4TP53ALDH1A1 | |
| SCHEMBL6205531 | 0.67 | MAPT (0.50) | GAANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL5795287 | 0.67 | SMN1; SMN2 (0.38) | GAASMN1; SMN2RNF4TP53ALDH1A1 | |
| SCHEMBL16227482 | 0.66 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2TP53KMT2A | |
| SCHEMBL13271512 | 0.66 | MET (0.63) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1560832-A1 | PYRIMIDO 4,5-D PYRIMIDINE DERIVATIVES WITH ANTICANCER ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2005-08-10 | — | — | EP | disclosed |
| WO-2004041822-A1 | PYRIMIDO[4,5-D]PYRIMIDINE DERIVATIVES WITH ANTICANCER ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2004-05-21 | — | — | WO | disclosed |