Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cyclizine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.96 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.96 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.96 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.96 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.96 |
| ▸ | DRD1 | P21728 | 3/20 | 0.96 |
| ▸ | DRD3 | P35462 | 3/20 | 0.96 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.96 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.96 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.96 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.96 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.96 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.96 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.96 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.96 |
| ▸ | HTR2A | P28223 | 1/20 | 0.96 |
| ▸ | HTR2C | P28335 | 1/20 | 0.96 |
| ▸ | HTR2B | P41595 | 1/20 | 0.96 |
| ▸ | TSHR | P16473 | 1/20 | 0.80 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclizine SCHEMBL19514707 | 1.00 | CYP2D6 (0.96) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| Cyclizine SCHEMBL4690 | 0.98 | CYP2D6 (1.00) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| Cyclizine SCHEMBL97826 | 0.94 | CYP2D6 (0.92) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| Chlorcyclizine SCHEMBL321657 | 0.89 | CYP2D6 (1.00) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| Cyclizine SCHEMBL5656056 | 0.89 | CYP2D6 (0.82) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| SCHEMBL2615164 | 0.87 | CYP2D6 (0.79) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| Chlorcyclizine SCHEMBL12157065 | 0.87 | KCNH2 (1.00) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| Chlorcyclizine SCHEMBL4383 | 0.87 | KCNH2 (1.00) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| Chlorcyclizine SCHEMBL16769331 | 0.87 | KCNH2 (1.00) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| Chlorcyclizine SCHEMBL13724147 | 0.87 | KCNH2 (1.00) | CYP2D6CHRM2ADRA2ACHRM1DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1977 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250337226-A1 | ELECTRICALLY INSULATED BOOM MOUNTABLE TEMPORARY CONDUCTOR GUARD STRUCTURE | QUANTA ASSOCIATES LP (US) | 2025-10-30 | — | — | US | claimed |
| US-12374872-B2 | Electrically insulated boom mountable temporary conductor guard structure | QUANTA ASSOCIATES, L.P. (US) | 2025-07-29 | — | — | US | claimed |
| CN-119825425-B | Large-span tunnel micro-sedimentation control method for pipe curtain pre-built structure | 北京交通大学 | 2025-05-27 | — | — | CN | claimed |
| CN-115221595-B | Method for calculating bearing capacity of gravel pellet pile based on composite foundation | 建研地基基础工程有限责任公司 | 2024-07-30 | — | — | CN | claimed |
| CN-117787527-B | Tour route intelligent planning method based on big data analysis technology | 东莞市城建规划设计院 | 2024-04-26 | — | — | CN | claimed |
| CN-117787527-A | Tour route intelligent planning method based on big data analysis technology | 东莞市城建规划设计院 | 2024-03-29 | — | — | CN | claimed |
| EP-4282044-A1 | ELECTRICALLY INSULATED BOOM MOUNTABLE TEMPORARY CONDUCTOR GUARD STRUCTURE | Quanta Associates, L.P. (US) | 2023-11-29 | — | — | EP | claimed |
| WO-2022217749-A1 | RAINWATER FILTERING GARDEN | 中国建筑设计研究院有限公司 | 2022-10-20 | — | — | WO | claimed |
| WO-2022164992-A1 | ELECTRICALLY INSULATED BOOM MOUNTABLE TEMPORARY CONDUCTOR GUARD STRUCTURE | QUANTA ASSOCIATES, L.P. (US) | 2022-08-04 | — | — | WO | claimed |
| US-20220239076-A1 | ELECTRICALLY INSULATED BOOM MOUNTABLE TEMPORARY CONDUCTOR GUARD STRUCTURE | QUANTA ASSOCIATES, L.P. | 2022-07-28 | — | — | US | claimed |
| EP-0608322-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1994-08-03 | — | — | EP | claimed |
| EP-0608320-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1994-08-03 | — | — | EP | claimed |
| WO-1994002176-A1 | PHARMACEUTICAL COMPOSITION FOR TOPICAL USE CONTAINING A CROSSLINKED CATIONIC POLYMER AND AN ALKOXYLATED ETHER | THE PROCTER & GAMBLE COMPANY (US) | 1994-02-03 | — | — | WO | claimed |
| WO-1993024154-A1 | BIODEGRADABLE CONTROLLED RELEASE MELT-SPUN DELIVERY SYSTEM | FUISZ TECHNOLOGIES, LTD. (US) | 1993-12-09 | — | — | WO | claimed |
| EP-0486563-B1 | CHEWING GUM COMPOSITION WITH ACCELERATED, CONTROLLED RELEASE OF ACTIVE AGENTS | FERTIN A/S (DK) | 1993-09-08 | — | — | EP | claimed |
| WO-1993007902-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1993-04-29 | — | — | WO | claimed |
| WO-1993007903-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1993-04-29 | — | — | WO | claimed |
| US-5053396-A | For treatment of symptoms associated with excessive alcohol intake, analgesic; nicotinamide or nicotinamide adenine dinucleotide | BLASS DAVID H (GB) | 1991-10-01 | — | — | US | claimed |
| EP-0351897-A2 | Skin penetration system for salts of amine-functional drugs | THE PROCTER & GAMBLE COMPANY (US) | 1990-01-24 | — | — | EP | claimed |
| US-4654209-A | NITROGLYCERINE PLUS STEROID, ANTIHISTAMINE, ANALGESIC, ANTIMICROBIAL | EUROCELTIQUE, S.A. (LU) | 1987-03-31 | — | — | US | claimed |