Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | CCR5 | P51681 | 5/20 | 0.45 |
| ▸ | F10 | P00742 | 3/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | CCL5 | P13501 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4690543 | 0.83 | CCR5 (0.46) | TSHRCCR5CCL5ALDH1A1 | |
| SCHEMBL4690555 | 0.81 | MAPK14 (0.52) | CCR5ADRB1HTR2AHTR2BSIGMAR1 | |
| SCHEMBL4692822 | 0.81 | SMYD3 (0.46) | CCR5CCL5ALDH1A1HTT | |
| SCHEMBL4691481 | 0.79 | CCR5 (0.49) | TSHRCCR5 | |
| SCHEMBL4690568 | 0.79 | CCR5 (0.67) | CCR5CCL5 | |
| SCHEMBL4691935 | 0.78 | KDM4E (0.42) | CCR5ADRB1HTR2AHTR2BSIGMAR1 | |
| SCHEMBL4694118 | 0.77 | KCNK3 (0.51) | CCR5MEN1KMT2AALDH1A1 | |
| SCHEMBL4690598 | 0.77 | CCR5 (0.55) | CCR5CCL5 | |
| SCHEMBL4690500 | 0.76 | F10 (0.43) | TSHRF10ADRB1HTR2AHTR2B | |
| SCHEMBL4695964 | 0.76 | CCR5 (0.54) | CCR5CCL5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |