Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4690595 | 0.88 | HCRTR1 (0.40) | LMNASMN1; SMN2ALDH1A1MAPTMEN1 | |
| SCHEMBL4694383 | 0.82 | SMN1; SMN2 (0.50) | LMNASMN1; SMN2ALDH1A1TSHRHTT | |
| SCHEMBL4692331 | 0.81 | MAPT (0.52) | LMNASMN1; SMN2ALDH1A1TSHRHTT | |
| SCHEMBL4693136 | 0.80 | MAPT (0.46) | LMNASMN1; SMN2ALDH1A1HTTMAPT | |
| SCHEMBL4695194 | 0.80 | TP53 (0.42) | LMNAALDH1A1TSHRHTTMAPT | |
| SCHEMBL4691620 | 0.80 | THRB (0.47) | LMNASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL4690632 | 0.80 | LMNA (0.44) | LMNASMN1; SMN2ALDH1A1TSHRHTT | |
| SCHEMBL4695171 | 0.79 | TP53 (0.40) | LMNASMN1; SMN2ALDH1A1TSHRHTT | |
| SCHEMBL4690733 | 0.79 | HCRTR1 (0.46) | MAPTMEN1GAAKMT2AHCRTR1 | |
| SCHEMBL4690677 | 0.79 | POLB (0.48) | LMNAMAPTMEN1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |