Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 11/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 11/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4690592 | 0.88 | LMNA (0.41) | HCRTR1HCRTR2KDM4EGAASMN1; SMN2 | |
| SCHEMBL4693564 | 0.83 | HRH4 (0.38) | HCRTR1HCRTR2KDM4EGAASMN1; SMN2 | |
| SCHEMBL4694388 | 0.82 | RAB9A (0.43) | HCRTR1HCRTR2SMN1; SMN2NPC1MAPT | |
| SCHEMBL4692337 | 0.81 | HCRTR1 (0.51) | HCRTR1HCRTR2KDM4EGAASMN1; SMN2 | |
| SCHEMBL4691625 | 0.81 | THRB (0.42) | HCRTR1HCRTR2KDM4EGAASMN1; SMN2 | |
| SCHEMBL4693141 | 0.80 | ALDH1A1 (0.45) | HCRTR1HCRTR2KDM4EGAASMN1; SMN2 | |
| SCHEMBL4695198 | 0.80 | KDM4E (0.39) | HCRTR1HCRTR2KDM4EGAASMN1; SMN2 | |
| SCHEMBL4690636 | 0.80 | ALDH1A1 (0.41) | KDM4EGAASMN1; SMN2MEN1MAPT | |
| SCHEMBL4695177 | 0.79 | SMN1; SMN2 (0.39) | HCRTR1HCRTR2KDM4EGAASMN1; SMN2 | |
| SCHEMBL4690742 | 0.79 | HCRTR1 (0.46) | HCRTR1HCRTR2KDM4EGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |