Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 2/20 | 0.57 |
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.35 |
| ▸ | HTR1A | P08908 | 4/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
| ▸ | DHODH | Q02127 | 1/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4693477 | 0.88 | CRHR1 (0.67) | CRHR1PDE10AHTR1ADHODHADORA3 | |
| SCHEMBL4693619 | 0.88 | CRHR1 (0.67) | CRHR1PDE10AHTR1ADHODHADORA3 | |
| SCHEMBL4695461 | 0.86 | CRHR1 (0.58) | CRHR1PDE10ADHODHADORA3PTGDR2 | |
| SCHEMBL3964355 | 0.83 | CRHR1 (0.79) | CRHR1PDE10APIK3CAROCK1 | |
| SCHEMBL4690582 | 0.78 | CRHR1 (0.53) | CRHR1ROCK1ADORA3 | |
| SCHEMBL4689862 | 0.76 | CRHR1 (0.45) | CRHR1PDE10AADORA3 | |
| SCHEMBL3963171 | 0.75 | CRHR1 (0.84) | CRHR1PDE10AROCK1 | |
| SCHEMBL3967632 | 0.72 | CRHR1 (1.00) | CRHR1PDE10AROCK1 | |
| SCHEMBL3970579 | 0.72 | CRHR1 (0.87) | CRHR1PDE10AROCK1 | |
| SCHEMBL13763358 | 0.72 | CRHR1 (1.00) | CRHR1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879896-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006107784-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2006-10-12 | — | — | WO | disclosed |