Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.67 |
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | GHSR | Q92847 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4693619 | 1.00 | CRHR1 (0.67) | CRHR1PDE10ADHODHCRHR2XDH | |
| SCHEMBL4695461 | 0.89 | CRHR1 (0.58) | CRHR1PDE10ADHODHADORA3PTGDR2 | |
| SCHEMBL4690737 | 0.88 | CRHR1 (0.57) | CRHR1PDE10ADHODHADORA3PTGDR2 | |
| SCHEMBL4690582 | 0.88 | CRHR1 (0.53) | CRHR1CRHR2ADORA3 | |
| SCHEMBL3963171 | 0.82 | CRHR1 (0.84) | CRHR1PDE10ACRHR2 | |
| SCHEMBL3967632 | 0.81 | CRHR1 (1.00) | CRHR1PDE10ACRHR2KDM4EMAPT | |
| SCHEMBL4689862 | 0.80 | CRHR1 (0.45) | CRHR1PDE10AADORA3MAPTHPGD | |
| SCHEMBL3970579 | 0.80 | CRHR1 (0.87) | CRHR1PDE10ACRHR2 | |
| SCHEMBL3967219 | 0.80 | CRHR1 (0.71) | CRHR1PDE10ACRHR2KDM4E | |
| SCHEMBL13763358 | 0.80 | CRHR1 (1.00) | CRHR1PDE10ACRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879896-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006107784-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2006-10-12 | — | — | WO | disclosed |