Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 5/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4693477 | 0.88 | CRHR1 (0.67) | CRHR1CRHR2ADORA3 | |
| SCHEMBL4693619 | 0.88 | CRHR1 (0.67) | CRHR1CRHR2ADORA3 | |
| SCHEMBL3965264 | 0.81 | CRHR1 (0.78) | CRHR1ROCK1CRHR2NPY5R | |
| SCHEMBL4689862 | 0.81 | CRHR1 (0.45) | CRHR1ADORA3 | |
| SCHEMBL4690737 | 0.78 | CRHR1 (0.57) | CRHR1ROCK1ADORA3 | |
| SCHEMBL4694546 | 0.77 | CRHR1 (0.39) | CRHR1CRHR2 | |
| SCHEMBL4694319 | 0.76 | CRHR1 (0.37) | CRHR1CRHR2ADORA3 | |
| SCHEMBL4787114 | 0.75 | TLR8 (0.38) | CRHR1CRHR2ADORA3 | |
| SCHEMBL4694406 | 0.73 | CRHR1 (0.33) | CRHR1 | |
| SCHEMBL3963171 | 0.72 | CRHR1 (0.84) | CRHR1ROCK1CRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879896-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006107784-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2006-10-12 | — | — | WO | disclosed |