Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.49 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4695900 | 0.93 | MAPT (0.51) | MAPTHCRTR1HCRTR2LMNAALOX12 | |
| SCHEMBL4691831 | 0.91 | MAPT (0.51) | MAPTLMNAALOX12SMN1; SMN2KMT2A | |
| SCHEMBL4689516 | 0.91 | MAPT (0.61) | MAPTLMNAALOX12SMN1; SMN2KMT2A | |
| SCHEMBL4692326 | 0.89 | CCR5 (0.51) | MAPTLMNAALOX12SMN1; SMN2KMT2A | |
| SCHEMBL4690733 | 0.89 | HCRTR1 (0.46) | MAPTHCRTR1HCRTR2KMT2ATP53 | |
| SCHEMBL4693609 | 0.87 | SMN1; SMN2 (0.52) | MAPTLMNAALOX12SMN1; SMN2KMT2A | |
| SCHEMBL4690931 | 0.86 | MAPT (0.51) | MAPTHCRTR1HCRTR2LMNASMN1; SMN2 | |
| SCHEMBL4692884 | 0.86 | LMNA (0.48) | MAPTLMNASMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL4690305 | 0.86 | MAPT (0.49) | MAPTLMNAALOX12SMN1; SMN2KMT2A | |
| SCHEMBL4691400 | 0.86 | KMT2A (0.50) | MAPTHCRTR1HCRTR2LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |