Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NPY2R | P49146 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MGLL | Q99685 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4689516 | 0.90 | MAPT (0.61) | SMN1; SMN2MAPTPOLBKMT2ATP53 | |
| SCHEMBL4690926 | 0.87 | MAPT (0.54) | SMN1; SMN2MAPTKMT2ADRD2DRD4 | |
| SCHEMBL4693613 | 0.87 | GFER (0.49) | SMN1; SMN2MAPTPOLBMEN1KMT2A | |
| SCHEMBL4692326 | 0.86 | CCR5 (0.51) | SMN1; SMN2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL4695950 | 0.86 | TERT (0.45) | SMN1; SMN2MAPTPOLBKMT2ARAB9A | |
| SCHEMBL4693892 | 0.86 | HCRTR1 (0.47) | SMN1; SMN2MAPTPOLBMEN1KMT2A | |
| SCHEMBL4695900 | 0.85 | MAPT (0.51) | SMN1; SMN2MAPTMEN1KMT2ANPSR1 | |
| SCHEMBL4691831 | 0.85 | MAPT (0.51) | SMN1; SMN2MAPTPOLBMEN1KMT2A | |
| SCHEMBL4694150 | 0.85 | NPY2R (0.51) | SMN1; SMN2MAPTPOLBKMT2ANPY2R | |
| SCHEMBL4690305 | 0.85 | MAPT (0.49) | SMN1; SMN2MAPTMEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |