Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31064460 | 0.83 | IDH1 (0.38) | — | |
| SCHEMBL31064457 | 0.81 | KMT2A (0.41) | — | |
| SCHEMBL31064594 | 0.81 | KMT2A (0.41) | — | |
| SCHEMBL24468301 | 0.80 | JAK3 (0.34) | JAK2JAK3 | |
| SCHEMBL29686056 | 0.80 | JAK3 (0.34) | JAK2JAK3 | |
| SCHEMBL17445189 | 0.80 | JAK3 (0.34) | JAK2JAK3 | |
| Hydrochloric Acid SCHEMBL31064608 | 0.80 | KMT2A (0.40) | — | |
| Hydrochloric Acid SCHEMBL31064700 | 0.77 | S1PR1 (0.39) | — | |
| SCHEMBL19965685 | 0.77 | AGBL2 (0.32) | — | |
| SCHEMBL469180 | 0.77 | AGBL2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120064181-A1 | P2X3 Receptor Antagonists for Treatment of Pain | MERCK SHARP & DOHME LLC | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120064181-A1 | P2X3 Receptor Antagonists for Treatment of Pain | P2RX3, P2RX1, P2RX2 | JAK2 3718/4885JAK3 3395/4885POLB 4302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.