Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 3/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.31 |
| ▸ | MUSK | O15146 | 1/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.30 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24468301 | 1.00 | JAK3 (0.34) | JAK3JAK2HTR2ASLC6A4KCNH2 | |
| SCHEMBL29686056 | 1.00 | JAK3 (0.34) | JAK3JAK2HTR2ASLC6A4KCNH2 | |
| SCHEMBL469213 | 0.80 | JAK2 (0.35) | JAK3JAK2 | |
| SCHEMBL10237035 | 0.80 | SLC6A3 (0.36) | JAK3JAK2BDKRB1 | |
| SCHEMBL2737358 | 0.79 | AGBL2 (0.32) | JAK3JAK2 | |
| SCHEMBL31187826 | 0.79 | KMT2A (0.47) | HTR2ASLC6A4KCNH2 | |
| SCHEMBL24468303 | 0.79 | KMT2A (0.47) | HTR2ASLC6A4KCNH2 | |
| SCHEMBL30841812 | 0.79 | KMT2A (0.47) | HTR2ASLC6A4KCNH2 | |
| Hydrochloric Acid SCHEMBL31137441 | 0.78 | KMT2A (0.46) | HTR2ASLC6A4KCNH2BDKRB1 | |
| SCHEMBL588357 | 0.78 | L3MBTL1 (0.43) | BDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411001-B1 | P2X3, RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN | MERCK SHARP & DOHME (US) | 2018-01-17 | — | — | EP | disclosed |
| US-9238647-B2 | P2X3 receptor antagonists for treatment of pain | MERCK SHARP & DOHME CORP. (US) | 2016-01-19 | — | — | US | disclosed |