Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | SPPL2A | Q8TCT8 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LAP3 | P28838 | 3/20 | 0.37 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.37 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5423864 | 0.85 | F2 (0.39) | CSNK1EF2SMN1; SMN2LMNASPPL2A | |
| SCHEMBL4692657 | 0.82 | CSNK1E (0.48) | CSNK1EF2LMNAEPHX1MAPT | |
| SCHEMBL4689485 | 0.80 | CSNK1E (0.50) | CSNK1EF2SMN1; SMN2EPHX1MMP2 | |
| SCHEMBL4694780 | 0.79 | CSNK1E (0.44) | CSNK1EF2SMN1; SMN2LMNAEPHX1 | |
| SCHEMBL4695898 | 0.79 | F2 (0.53) | CSNK1EF2LMNAMAPTMEN1 | |
| SCHEMBL7300383 | 0.77 | CSNK1E (0.54) | CSNK1EF2EPHX1MMP2SLC15A1 | |
| SCHEMBL3357054 | 0.77 | LMNA (0.50) | CSNK1EF2LMNAMEN1KMT2A | |
| SCHEMBL4694678 | 0.76 | MAPT (0.45) | CSNK1EF2SMN1; SMN2LMNASLC15A1 | |
| Hydrochloric Acid SCHEMBL7310009 | 0.76 | CSNK1E (0.53) | CSNK1EF2EPHX1MMP2SLC15A1 | |
| SCHEMBL4689625 | 0.75 | F2 (0.47) | CSNK1EF2SMN1; SMN2LMNAMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692143-B1 | TRICYCLIC INDOLE HYDROXYETHYLAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2008-11-12 | — | — | EP | disclosed |