Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692657 | 0.86 | CSNK1E (0.48) | F2HTTMAPTCSNK1ELMNA | |
| SCHEMBL4694821 | 0.85 | F2 (0.51) | F2MAPTCSNK1EGAAALDH1A1 | |
| SCHEMBL5428001 | 0.83 | F2 (0.40) | F2THRBHTTCSNK1EGAA | |
| SCHEMBL4692605 | 0.81 | HTT (0.50) | F2HTTMAPTCSNK1EALDH1A1 | |
| SCHEMBL4695052 | 0.80 | ALDH1A1 (0.45) | F2HTTMAPTCSNK1ESMN1; SMN2 | |
| SCHEMBL4689485 | 0.75 | CSNK1E (0.50) | F2HTTMAPTCSNK1ESMN1; SMN2 | |
| SCHEMBL4692139 | 0.75 | CSNK1E (0.44) | F2MAPTCSNK1ESMN1; SMN2LMNA | |
| SCHEMBL5431634 | 0.75 | F2 (0.41) | F2CSNK1ELMNA | |
| SCHEMBL4038318 | 0.75 | DNM1 (0.51) | F2CSNK1ETACR1 | |
| SCHEMBL4695898 | 0.75 | F2 (0.53) | F2MAPTCSNK1EGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692143-B1 | TRICYCLIC INDOLE HYDROXYETHYLAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2008-11-12 | — | — | EP | disclosed |