Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 3/20 | 0.45 |
| ▸ | GBA1 | P04062 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4688827 | 0.90 | F2 (0.52) | F2MAPTMEN1KMT2ATDP1 | |
| SCHEMBL4692657 | 0.82 | CSNK1E (0.48) | F2MAPTCSNK1ELMNASCN4A | |
| SCHEMBL6327499 | 0.79 | MAPT (0.56) | MAPTMEN1KMT2ATDP1KDM4E | |
| SCHEMBL5216965 | 0.79 | BCHE (0.69) | F2MEN1KMT2ABCHEKDM4E | |
| SCHEMBL4692139 | 0.79 | CSNK1E (0.44) | F2MAPTMEN1KMT2ACSNK1E | |
| SCHEMBL4694821 | 0.79 | F2 (0.51) | F2MAPTTDP1CSNK1EALDH1A1 | |
| SCHEMBL4695907 | 0.78 | F2 (0.47) | F2MAPTMEN1KMT2ATDP1 | |
| SCHEMBL4689950 | 0.78 | CRHBP (0.49) | F2KMT2A | |
| SCHEMBL4044406 | 0.77 | BCHE (0.55) | F2KMT2ABCHEKDM4EALDH1A1 | |
| SCHEMBL4689485 | 0.76 | CSNK1E (0.50) | F2MAPTCSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692143-B1 | TRICYCLIC INDOLE HYDROXYETHYLAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2008-11-12 | — | — | EP | disclosed |