Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 6/20 | 0.42 |
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.41 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.35 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694054 | 0.95 | CCR5 (0.42) | CCR5UTS2RDGAT2ROCK2ROCK1 | |
| SCHEMBL4691949 | 0.94 | UTS2R (0.49) | CCR5UTS2RDGAT2ROCK2ROCK1 | |
| SCHEMBL4691249 | 0.93 | CCR5 (0.44) | CCR5UTS2RDGAT2ROCK2ROCK1 | |
| SCHEMBL4690858 | 0.93 | CCR5 (0.48) | CCR5UTS2RDGAT2ROCK2ROCK1 | |
| SCHEMBL4694765 | 0.92 | CCR5 (0.44) | CCR5UTS2RDGAT2ROCK2ROCK1 | |
| SCHEMBL4690242 | 0.92 | CCR5 (0.43) | CCR5UTS2RDGAT2ROCK2ROCK1 | |
| SCHEMBL4690226 | 0.91 | CCR5 (0.46) | CCR5UTS2RITGB1SIGMAR1 | |
| SCHEMBL4696133 | 0.91 | CCR5 (0.46) | CCR5UTS2RDGAT2LMNAGAA | |
| SCHEMBL4696387 | 0.91 | CCR5 (0.47) | CCR5UTS2RROCK2ROCK1 | |
| SCHEMBL4691873 | 0.90 | ACHE (0.45) | CCR5DGAT2ROCK2ROCK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |