Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 9/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.42 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5223403 | 0.99 | EPHX2 (0.42) | EPHX2F2CSNK1EEPHX1CXCR3 | |
| SCHEMBL4749760 | 0.81 | HPGD (0.41) | EPHX2F2CSNK1EEPHX1SMN1; SMN2 | |
| SCHEMBL4749765 | 0.81 | HPGD (0.41) | EPHX2F2CSNK1EEPHX1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5222193 | 0.80 | HPGD (0.40) | EPHX2F2CSNK1EEPHX1SMN1; SMN2 | |
| SCHEMBL5805296 | 0.79 | GRIN2B (0.48) | F2CSNK1EEPHX1 | |
| SCHEMBL14253003 | 0.79 | GRIN2B (0.48) | F2CSNK1EEPHX1 | |
| SCHEMBL4047960 | 0.79 | GRIN2B (0.48) | F2CSNK1EEPHX1 | |
| Hydrochloric Acid SCHEMBL6111346 | 0.77 | GRIN2B (0.47) | F2CSNK1EEPHX1 | |
| SCHEMBL5930121 | 0.76 | ANPEP (0.52) | F2CSNK1EEPHX1 | |
| SCHEMBL4689948 | 0.76 | F2 (0.47) | F2CSNK1EEPHX1MMP2SLC15A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692143-B1 | TRICYCLIC INDOLE HYDROXYETHYLAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2008-11-12 | — | — | EP | disclosed |