Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 2/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.35 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.35 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4749760 | 1.00 | HPGD (0.41) | HPGDSMN1; SMN2F2CSNK1ELTA4H | |
| Hydrochloric Acid SCHEMBL5222193 | 0.99 | HPGD (0.40) | HPGDSMN1; SMN2F2CSNK1ELTA4H | |
| SCHEMBL4692382 | 0.81 | EPHX2 (0.43) | SMN1; SMN2F2CSNK1EEPHX2EPHX1 | |
| Hydrochloric Acid SCHEMBL5223403 | 0.80 | EPHX2 (0.42) | SMN1; SMN2F2CSNK1EEPHX2EPHX1 | |
| SCHEMBL4042402 | 0.78 | REN (0.47) | HPGDSMN1; SMN2ALDH1A1EPHX2HSD17B10 | |
| SCHEMBL14253003 | 0.78 | GRIN2B (0.48) | F2CSNK1EEPHX1 | |
| SCHEMBL5805296 | 0.78 | GRIN2B (0.48) | F2CSNK1EEPHX1 | |
| SCHEMBL4047960 | 0.78 | GRIN2B (0.48) | F2CSNK1EEPHX1 | |
| Hydrochloric Acid SCHEMBL6111346 | 0.77 | GRIN2B (0.47) | F2CSNK1EEPHX1 | |
| SCHEMBL5225345 | 0.77 | KLK5 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692143-B1 | TRICYCLIC INDOLE HYDROXYETHYLAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2008-11-12 | — | — | EP | disclosed |