Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | LIPE | Q05469 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 4/20 | 0.38 |
| ▸ | MMP1 | P03956 | 2/20 | 0.38 |
| ▸ | MMP3 | P08254 | 2/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.38 |
| ▸ | ADAM9 | Q13443 | 2/20 | 0.38 |
| ▸ | ACE | P12821 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13681723 | 0.87 | NOTUM (0.44) | NOTUMCHEK1JAK2LIPEMMP9 | |
| SCHEMBL5351764 | 0.77 | NAMPT (0.44) | MEN1KMT2ABCHE | |
| SCHEMBL7434906 | 0.77 | NAMPT (0.44) | MEN1KMT2ABCHE | |
| SCHEMBL2092090 | 0.75 | ACE (0.54) | NOTUMCHEK1JAK2ACEPOLB | |
| SCHEMBL13971489 | 0.75 | ACE (0.54) | NOTUMCHEK1JAK2ACEPOLB | |
| SCHEMBL3154327 | 0.75 | ACE (0.54) | NOTUMCHEK1JAK2ACEPOLB | |
| SCHEMBL32676972 | 0.75 | ACE (0.54) | NOTUMCHEK1JAK2ACEPOLB | |
| SCHEMBL10954465 | 0.73 | ACE (0.68) | ACE | |
| SCHEMBL13181522 | 0.73 | MAOA (0.38) | NOTUMACEPOLBAPOBEC3AAPOBEC3G | |
| SCHEMBL1445012 | 0.72 | AADAT (0.41) | NOTUMMEN1KMT2APOLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| WO-2007082666-A1 | ACYLAMINOIMIDAZOLES | BAYER HEALTHCARE AG (DE) | 2007-07-26 | — | — | WO | disclosed |