Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 10/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 9/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4690738 | 0.93 | HCRTR1 (0.46) | HCRTR2HCRTR1ALDH1A1HPGDTNF | |
| SCHEMBL4694375 | 0.93 | HCRTR1 (0.40) | HCRTR2HCRTR1ALDH1A1HPGDTNF | |
| SCHEMBL4692703 | 0.90 | HCRTR1 (0.48) | HCRTR2HCRTR1ALDH1A1TNFP2RX7 | |
| SCHEMBL4692886 | 0.90 | ALDH1A1 (0.42) | HCRTR2HCRTR1ALDH1A1HPGDTNF | |
| SCHEMBL4692692 | 0.87 | HCRTR1 (0.45) | HCRTR2HCRTR1ALDH1A1TNF | |
| SCHEMBL4690680 | 0.87 | HCRTR1 (0.42) | HCRTR2HCRTR1ALDH1A1HPGDTNF | |
| SCHEMBL4690403 | 0.87 | HCRTR1 (0.39) | HCRTR2HCRTR1ALDH1A1HPGDTNF | |
| SCHEMBL4694334 | 0.87 | HCRTR1 (0.43) | HCRTR2HCRTR1TNF | |
| SCHEMBL4691396 | 0.87 | HCRTR1 (0.39) | HCRTR2HCRTR1TNF | |
| SCHEMBL4691868 | 0.87 | HCRTR1 (0.47) | HCRTR2HCRTR1ALDH1A1TNFP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |