Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 4/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | CPS1 | P31327 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.36 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692712 | 0.93 | HCRTR1 (0.43) | HCRTR1HCRTR2ALDH1A1P2RX7KCNK3 | |
| SCHEMBL4692703 | 0.93 | HCRTR1 (0.48) | HCRTR1HCRTR2ALDH1A1P2RX7KCNK3 | |
| SCHEMBL4693718 | 0.91 | TSHR (0.38) | HCRTR1HCRTR2DPP4SMN1; SMN2 | |
| SCHEMBL4691904 | 0.90 | HCRTR1 (0.46) | HCRTR1HCRTR2ALDH1A1KCNK3KCNK9 | |
| SCHEMBL4692106 | 0.90 | HCRTR1 (0.50) | HCRTR1HCRTR2P2RX7KCNK3KCNK9 | |
| SCHEMBL4694969 | 0.89 | HCRTR1 (0.38) | HCRTR1HCRTR2DPP4P2RX7KCNK3 | |
| SCHEMBL4694815 | 0.89 | HCRTR1 (0.37) | HCRTR1HCRTR2DPP4 | |
| SCHEMBL4691612 | 0.89 | KDM1A (0.38) | ALDH1A1MAPK1SMN1; SMN2KMT2A | |
| SCHEMBL4694083 | 0.88 | TSHR (0.40) | HCRTR1HCRTR2DPP4ALDH1A1SMN1; SMN2 | |
| SCHEMBL4693169 | 0.88 | HCRTR1 (0.50) | HCRTR1HCRTR2P2RX7KCNK3KCNK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |