Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 8/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 8/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.33 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | TACR3 | P29371 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694165 | 0.92 | HCRTR1 (0.48) | HCRTR1HCRTR2HPGDTNFKCNK3 | |
| SCHEMBL4694375 | 0.89 | HCRTR1 (0.40) | HCRTR1HCRTR2HPGDUSP2TNF | |
| SCHEMBL4692944 | 0.89 | HCRTR1 (0.41) | HCRTR1HCRTR2KCNK3KCNK9P2RX7 | |
| SCHEMBL4692712 | 0.89 | HCRTR1 (0.43) | HCRTR1HCRTR2TNFKCNK3KCNK9 | |
| SCHEMBL4693718 | 0.89 | TSHR (0.38) | HCRTR1HCRTR2HPGDTNFDPP4 | |
| SCHEMBL4691904 | 0.88 | HCRTR1 (0.46) | HCRTR1HCRTR2USP2TNFKCNK3 | |
| SCHEMBL4694763 | 0.88 | HCRTR1 (0.37) | HCRTR1HCRTR2TNFDPP4DPP8 | |
| SCHEMBL4694083 | 0.88 | TSHR (0.40) | HCRTR1HCRTR2HPGDTNFDPP4 | |
| SCHEMBL4690680 | 0.88 | HCRTR1 (0.42) | HCRTR1HCRTR2HPGDTNFP2RX7 | |
| SCHEMBL4692703 | 0.87 | HCRTR1 (0.48) | HCRTR1HCRTR2TNFKCNK3KCNK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |