Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 6/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4690404 | 0.91 | CCR5 (0.41) | MAPTSMN1; SMN2POLBTP53CCR5 | |
| SCHEMBL4694337 | 0.87 | CCR5 (0.43) | MAPTSMN1; SMN2CCR5HTTL3MBTL1 | |
| SCHEMBL4693007 | 0.86 | HTT (0.43) | MAPTSMN1; SMN2TP53HTTL3MBTL1 | |
| SCHEMBL3281865 | 0.84 | CCR5 (0.52) | MAPTSMN1; SMN2CCR5HTTLMNA | |
| SCHEMBL4695962 | 0.82 | MEN1 (0.41) | MAPTSMN1; SMN2CCR5HTTL3MBTL1 | |
| SCHEMBL4691511 | 0.82 | CCR5 (0.54) | MAPTCCR5LMNAALDH1A1GAA | |
| SCHEMBL4694791 | 0.82 | MAPT (0.47) | MAPTCCR5HTTLMNAALDH1A1 | |
| SCHEMBL4694816 | 0.82 | CCR5 (0.44) | MAPTSMN1; SMN2CCR5HTTL3MBTL1 | |
| SCHEMBL4693310 | 0.82 | CCR5 (0.42) | MAPTSMN1; SMN2CCR5HTTL3MBTL1 | |
| SCHEMBL4695514 | 0.81 | MAPT (0.40) | MAPTSMN1; SMN2CCR5HTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |