Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 2/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | ATP4A | P20648 | 2/20 | 0.34 |
| ▸ | ATP4B | P51164 | 2/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.30 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.30 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.30 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.30 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3964678 | 0.90 | CRHR1 (0.48) | CRHR1CRHR2ATP4AATP4BPSEN1 | |
| SCHEMBL3966664 | 0.84 | CRHR1 (0.46) | CRHR1CRHR2ATP4AATP4BPSEN1 | |
| SCHEMBL4693232 | 0.84 | ATP4A (0.35) | ATP4AATP4BNR1I2HSD11B1NR1H2 | |
| SCHEMBL3967917 | 0.83 | CRHR1 (0.51) | CRHR1CRHR2PSEN1PSEN2APH1B | |
| SCHEMBL13763355 | 0.82 | CRHR1 (0.48) | CRHR1CRHR2SMPD3 | |
| SCHEMBL3968253 | 0.82 | CRHR1 (0.48) | CRHR1CRHR2SMPD3 | |
| SCHEMBL3962678 | 0.82 | CRHR1 (0.48) | CRHR1CRHR2SMPD3 | |
| SCHEMBL3966790 | 0.81 | CRHR1 (0.49) | CRHR1CRHR2SMPD3 | |
| SCHEMBL3971785 | 0.80 | CRHR1 (0.45) | CRHR1CRHR2PSEN1PSEN2APH1B | |
| SCHEMBL13763354 | 0.80 | CRHR1 (0.46) | CRHR1CRHR2SMPD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879896-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006107784-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2006-10-12 | — | — | WO | disclosed |