Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 2/20 | 0.35 |
| ▸ | ATP4B | P51164 | 2/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.31 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4693231 | 0.84 | CRHR1 (0.45) | ATP4AATP4BNR1I2HSD11B1NR1H2 | |
| SCHEMBL4695451 | 0.84 | TLR8 (0.32) | TLR8SMPD3 | |
| SCHEMBL4787114 | 0.80 | TLR8 (0.38) | TLR8SMPD3 | |
| SCHEMBL4689722 | 0.73 | CRHR1 (0.32) | TLR8 | |
| SCHEMBL4694389 | 0.69 | CYP2A6 (0.36) | TLR8SMPD3 | |
| SCHEMBL4695617 | 0.69 | OPRL1 (0.34) | TLR8 | |
| SCHEMBL3935197 | 0.67 | SMPD3 (0.35) | SMPD3 | |
| SCHEMBL4689715 | 0.66 | CRHR1 (0.31) | TLR8 | |
| SCHEMBL4694546 | 0.66 | CRHR1 (0.39) | TLR8 | |
| SCHEMBL4694319 | 0.66 | CRHR1 (0.37) | TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879896-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006107784-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2006-10-12 | — | — | WO | disclosed |