Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.70 |
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.64 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.56 |
| ▸ | MMP13 | P45452 | 1/20 | 0.56 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6024439 | 0.88 | NPC1 (0.75) | ALDH1A1NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL7296744 | 0.86 | SPHK2 (0.80) | ALDH1A1MAPTHTTSPHK2SPHK1 | |
| SCHEMBL3201438 | 0.82 | ALDH1A1 (1.00) | ALDH1A1MAPTHTTNPC1RAB9A | |
| SCHEMBL4754917 | 0.82 | ALDH1A1 (0.78) | ALDH1A1MAPTHTTNPC1RAB9A | |
| SCHEMBL19634295 | 0.82 | SPHK2 (0.58) | ALDH1A1MAPTHTTSPHK2SPHK1 | |
| SCHEMBL4693214 | 0.81 | ALDH1A1 (0.67) | ALDH1A1MAPTHTTNPC1RAB9A | |
| SCHEMBL16685001 | 0.80 | NPC1 (0.83) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3729907 | 0.79 | NPC1 (0.75) | ALDH1A1MAPTHTTNPC1RAB9A | |
| SCHEMBL15618832 | 0.79 | RAB9A (0.77) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3540405 | 0.78 | SMN1; SMN2 (0.71) | ALDH1A1MAPTHTTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1521757-B1 | TRICYCLIC SPIROPIPERIDINES OR SPIROPYRROLIDINES | ASTRAZENECA AB (SE) | 2008-01-30 | — | — | EP | disclosed |