Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 2/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.31 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2270437 | 0.72 | RAB9A (0.38) | MAPK14MAPK13MAPK12MAPK11CCNA2 | |
| SCHEMBL12401951 | 0.70 | IRAK4 (0.37) | MAPK14MAPK13MAPK12MAPK11CCNA2 | |
| SCHEMBL2275901 | 0.68 | KMT2A (0.40) | MAPK14MAPK13MAPK12MAPK11CCNA2 | |
| SCHEMBL2273133 | 0.65 | MAPK14 (0.37) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL14619279 | 0.65 | MAPK14 (0.36) | MAPK14MAPK13MAPK12MAPK11CCNA2 | |
| SCHEMBL2279956 | 0.65 | IRAK4 (0.52) | MAPK14MAPK13MAPK12MAPK11CCNA2 | |
| SCHEMBL9347326 | 0.65 | CES2 (0.42) | ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL2275204 | 0.65 | MAPK14 (0.46) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL12373301 | 0.64 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5071497 | 0.63 | NFE2L2 (0.38) | ALDH1A1MAPTMEN1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910348-A2 | BENZOTHIAZOLE AND AZABENZOTHIAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007016392-A2 | BENZOTHIAZOLE AND AZABENZOTHIAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-02-08 | — | — | WO | disclosed |