Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | AGER | Q15109 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2167765 | 0.88 | HTT (0.60) | ACHEAGERHTTLMNAPPARD | |
| SCHEMBL2168473 | 0.83 | LTA4H (0.61) | ACHELTA4HCYP1A2CYP2D6SMN1; SMN2 | |
| SCHEMBL8357711 | 0.81 | LMNA (0.63) | ACHEAURKBAGERMAPTHTT | |
| SCHEMBL8582569 | 0.80 | PPARD (0.52) | MAPTLTA4HPPARDCYP1A2CYP2D6 | |
| SCHEMBL18612365 | 0.79 | AURKB (0.48) | AURKBMAPTHTTLMNACYP1A2 | |
| SCHEMBL10654126 | 0.78 | PTPN1 (0.48) | MAPTLMNAPPARDKMT2AMEN1 | |
| SCHEMBL12667940 | 0.77 | TDP1 (0.48) | MAPTLTA4HPPARDCYP1A2CYP2D6 | |
| SCHEMBL20481222 | 0.77 | MAPT (0.44) | AURKBMAPTHTTLMNAPPARD | |
| SCHEMBL8684173 | 0.77 | PPARA (0.45) | AURKBMAPTHTTLMNACYP1A2 | |
| SCHEMBL8686061 | 0.77 | PPARA (0.45) | AURKBMAPTHTTLTA4HLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660492-B1 | BENZIMIDAZOLE, BENZTHIAZOLE AND BENZOXAZOLE DERIVATIVES AND THEIR USE AS LTA4H MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-08-20 | — | — | EP | disclosed |