Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUAK1 | O60285 | 1/20 | 0.61 |
| ▸ | NTRK1 | P04629 | 17/20 | 0.50 |
| ▸ | IGF1R | P08069 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.37 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.37 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4698140 | 0.84 | NTRK1 (0.66) | NUAK1NTRK1IGF1R | |
| SCHEMBL4696455 | 0.84 | NTRK1 (0.64) | NUAK1NTRK1 | |
| SCHEMBL4696211 | 0.83 | NTRK1 (0.61) | NUAK1NTRK1 | |
| SCHEMBL4697302 | 0.83 | NTRK1 (0.55) | NUAK1NTRK1 | |
| SCHEMBL4697195 | 0.77 | NTRK1 (0.47) | NUAK1NTRK1NTRK3NTRK2 | |
| SCHEMBL3136977 | 0.76 | NUAK1 (1.00) | NUAK1NTRK1IGF1R | |
| SCHEMBL4698219 | 0.75 | NTRK1 (0.59) | NUAK1NTRK1IGF1R | |
| SCHEMBL3424837 | 0.73 | NTRK1 (0.60) | NUAK1NTRK1IGF1RNTRK3NTRK2 | |
| SCHEMBL3129628 | 0.71 | NUAK1 (0.60) | NUAK1NTRK1IGF1RNTRK3NTRK2 | |
| SCHEMBL4693854 | 0.71 | NTRK1 (0.59) | NUAK1NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853588-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-06-18 | — | — | EP | disclosed |