Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 11/20 | 0.59 |
| ▸ | CDK9 | P50750 | 4/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.42 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4696455 | 0.90 | NTRK1 (0.64) | NTRK1CDK9CCNT1NUAK1JAK2 | |
| SCHEMBL56866 | 0.84 | NTRK1 (0.52) | NTRK1CDK9CCNT1DYRK1ACLK4 | |
| SCHEMBL4694146 | 0.84 | NTRK1 (0.53) | NTRK1CCNT1IGF1RPIM1 | |
| SCHEMBL4698140 | 0.77 | NTRK1 (0.66) | NTRK1NUAK1IGF1RCLK4 | |
| SCHEMBL4694035 | 0.77 | NTRK1 (0.54) | NTRK1JAK2IGF1RPIM1 | |
| SCHEMBL4693854 | 0.75 | NTRK1 (0.59) | NTRK1NUAK1JAK2 | |
| SCHEMBL56800 | 0.75 | NTRK1 (0.79) | NTRK1JAK2 | |
| SCHEMBL4750903 | 0.75 | NTRK1 (0.79) | NTRK1JAK2 | |
| SCHEMBL4695215 | 0.75 | NUAK1 (0.61) | NTRK1NUAK1IGF1R | |
| SCHEMBL4697091 | 0.75 | NTRK1 (0.65) | NTRK1NUAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853588-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-06-18 | — | — | EP | disclosed |