Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 6/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 5/20 | 0.41 |
| ▸ | IGF1R | P08069 | 2/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | BMX | P51813 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694146 | 0.86 | NTRK1 (0.53) | NTRK1CCNA2CDK2CCNA1IGF1R | |
| SCHEMBL4693854 | 0.74 | NTRK1 (0.59) | NTRK1JAK2 | |
| SCHEMBL4696455 | 0.74 | NTRK1 (0.64) | NTRK1MAPTPIM1JAK2 | |
| SCHEMBL4698219 | 0.72 | NTRK1 (0.59) | NTRK1IGF1RPIM1JAK2 | |
| SCHEMBL4750903 | 0.72 | NTRK1 (0.79) | NTRK1JAK2 | |
| SCHEMBL4694035 | 0.72 | NTRK1 (0.54) | NTRK1IGF1RPIM1JAK2 | |
| SCHEMBL56800 | 0.72 | NTRK1 (0.79) | NTRK1JAK2 | |
| SCHEMBL4695287 | 0.71 | NTRK1 (0.62) | NTRK1CCNA2CDK2CCNA1IGF1R | |
| SCHEMBL4696570 | 0.71 | NTRK1 (0.75) | NTRK1IGF1RJAK2 | |
| SCHEMBL3774702 | 0.71 | NTRK1 (1.00) | NTRK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853588-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-06-18 | — | — | EP | disclosed |