Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 3/20 | 0.76 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | AGXT | P21549 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.44 |
| ▸ | HTR3B | O95264 | 2/20 | 0.44 |
| ▸ | HTR3A | P46098 | 2/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.44 |
| ▸ | TACR1 | P25103 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24017152 | 0.88 | PNMT (0.74) | PNMTTAAR1CYP3A4IDO1AGXT | |
| SCHEMBL24017049 | 0.88 | PNMT (0.74) | PNMTTAAR1CYP3A4IDO1AGXT | |
| SCHEMBL14478283 | 0.86 | PNMT (1.00) | PNMTTAAR1CYP3A4IDO1AGXT | |
| SCHEMBL266685 | 0.86 | PNMT (1.00) | PNMTTAAR1CYP3A4IDO1AGXT | |
| SCHEMBL30363681 | 0.86 | PNMT (1.00) | PNMTTAAR1CYP3A4IDO1AGXT | |
| Hydrochloric Acid SCHEMBL30559514 | 0.85 | PNMT (0.96) | PNMTTAAR1CYP3A4IDO1AGXT | |
| SCHEMBL21076141 | 0.81 | PNMT (0.69) | PNMTTAAR1CYP3A4IDO1AGXT | |
| SCHEMBL16379378 | 0.81 | PNMT (0.69) | PNMTTAAR1CYP3A4IDO1AGXT | |
| SCHEMBL777207 | 0.80 | PNMT (0.74) | PNMTTAAR1CYP3A4IDO1AGXT | |
| SCHEMBL4693239 | 0.79 | TAAR1 (0.50) | PNMTTAAR1IDO1SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1375489-B1 | MEDICINAL COMPOSITION CONTAINING 1,3-THIAZINE DERIVATIVE | SHIONOGI & CO (JP) | 2008-08-20 | — | — | EP | disclosed |
| US-6916806-B2 | Medicinal composition containing 1,3-thiazine derivative | SHIONOGI & CO., LTD. (JP) | 2005-07-12 | — | — | US | disclosed |
| US-20040116326-A1 | Medicinal composition containing 1,3-thiazine derivative | SHIONOGI & CO., LTD. (JP) | 2004-06-17 | — | — | US | disclosed |
| EP-1375489-A1 | MEDICINAL COMPOSITION CONTAINING 1,3-THIAZINE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2004-01-02 | — | — | EP | disclosed |