Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 4/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PRNP | P04156 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | FNTA | P49354 | 1/20 | 0.44 |
| ▸ | FNTB | P49356 | 1/20 | 0.44 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2327593 | 0.86 | ALDH1A1 (0.50) | MAPK1CA2CA1NPSR1ALDH1A1 | |
| SCHEMBL3955074 | 0.86 | GAA (0.55) | NPSR1ALDH1A1SMN1; SMN2LMNAPKM | |
| SCHEMBL4740890 | 0.86 | GAA (0.55) | NPSR1ALDH1A1SMN1; SMN2LMNAPKM | |
| SCHEMBL14850410 | 0.86 | FOLH1 (0.44) | HTTALDH1A1 | |
| Fluoride SCHEMBL28465175 | 0.84 | GAA (0.53) | NPSR1ALDH1A1SMN1; SMN2LMNAPKM | |
| SCHEMBL18204163 | 0.84 | CA1 (0.51) | HTTMAPK1CA2CA1NPSR1 | |
| SCHEMBL17634328 | 0.84 | LMNA (0.47) | MAPK1CA2CA1NPSR1ALDH1A1 | |
| SCHEMBL16013365 | 0.82 | ALDH1A1 (0.48) | MAPK1CA2CA1NPSR1ALDH1A1 | |
| SCHEMBL19512080 | 0.81 | MAPK1 (0.46) | MAPK1NPSR1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5497952 | 0.80 | FOLH1 (0.59) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853588-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-06-18 | — | — | EP | disclosed |