Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 15/20 | 0.58 |
| ▸ | ESR2 | Q92731 | 14/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18386353 | 0.81 | CCR1 (0.38) | ESR1ESR2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL5879161 | 0.81 | ESR1 (0.37) | ESR1ESR2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL11149256 | 0.81 | ESR1 (0.58) | ESR1ESR2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL988872 | 0.81 | TRPA1 (0.42) | ESR1ESR2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL16812986 | 0.79 | ESR1 (0.60) | ESR1ESR2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL10600837 | 0.75 | ESR1 (0.63) | ESR1ESR2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7099557 | 0.75 | ESR1 (0.63) | ESR1ESR2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL434696 | 0.74 | ESR1 (0.58) | ESR1ESR2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL29043856 | 0.74 | ESR1 (0.44) | ESR1ESR2ALDH1A1CYP1A2CYP3A4 | |
| Diarylpropionitrile SCHEMBL1940848 | 0.73 | ESR2 (1.00) | ESR1ESR2ALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013057743-A1 | PROCESS FOR THE PREPARATION OF AN ARYL OXIME AND SALTS THEREOF | CONNEXIOS LIFE SCIENCES PVT. LTD (IN) | 2013-04-25 | — | — | WO | disclosed |
| EP-1419160-B1 | METHOD FOR THE PRODUCTION OF 6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2,3-DIHYDRO-1H-PYRROLIZIN-5-YLACETIC ACID | MERCKLE GMBH (DE) | 2008-12-10 | — | — | EP | disclosed |
| CN-1266152-C | Method for the production of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizin-5-ylacetic acid | MERCKLE GMBH (DE) | 2006-07-26 | — | — | CN | disclosed |
| US-7078535-B2 | Method for the production of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizin-5-ylacetic acid | MERCKLE GMBH (DE) | 2006-07-18 | — | — | US | disclosed |
| US-20040236117-A1 | Method for the production of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizin-5-ylacetic acid | MERCKLE GMBH (DE) | 2004-11-25 | — | — | US | disclosed |
| CN-1545516-A | Process for producing 6- (4-chlorophenyl) -2, 2-dimethyl-7-phenyl-2, 3-dihydro-1H-pyrrolizin-5-ylacetic acid | ��Ĭ���� | 2004-11-10 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040236117-A1 | Method for the production of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizin-5-ylacetic acid | KMO, HPD, PDK4 | ESR1 2805/4885ESR2 1873/4885ALDH1A1 472/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.