Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | CCR5 | P51681 | 10/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | CCL5 | P13501 | 4/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | ARAF | P10398 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694791 | 0.92 | MAPT (0.47) | MAPTGAAEPHX2CCR5ALDH1A1 | |
| SCHEMBL4690678 | 0.91 | ALDH1A1 (0.41) | MAPTGAACCR5ALDH1A1CCL5 | |
| SCHEMBL4695365 | 0.91 | BRAF (0.39) | MAPTGAAEPHX2CCR5ALDH1A1 | |
| SCHEMBL4691999 | 0.90 | MAPT (0.51) | MAPTGAAEPHX2CCR5ALDH1A1 | |
| SCHEMBL4691185 | 0.88 | P2RX7 (0.43) | MAPTCCR5ALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL4694236 | 0.87 | EPHX2 (0.44) | MAPTGAAEPHX2ALDH1A1 | |
| SCHEMBL4694025 | 0.87 | P2RX7 (0.48) | — | |
| SCHEMBL4693018 | 0.87 | NPY2R (0.47) | MAPTGAACCR5ALDH1A1 | |
| SCHEMBL3281865 | 0.86 | CCR5 (0.52) | MAPTGAACCR5ALDH1A1HCRTR1 | |
| SCHEMBL4695514 | 0.86 | MAPT (0.40) | MAPTGAACCR5ALDH1A1HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |