Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 12/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 12/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.38 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4693245 | 0.88 | MAPT (0.39) | RAB9ASMN1; SMN2HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL4693141 | 0.87 | ALDH1A1 (0.45) | SMN1; SMN2HCRTR1HCRTR2ALDH1A1MAPT | |
| SCHEMBL4694383 | 0.87 | SMN1; SMN2 (0.50) | RAB9AHPGDTSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL4690931 | 0.85 | MAPT (0.51) | RAB9ATSHRSMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL4695902 | 0.84 | HCRTR2 (0.48) | HCRTR1HCRTR2ALDH1A1MAPTHTT | |
| SCHEMBL4690506 | 0.84 | HCRTR1 (0.52) | TSHRHCRTR1HCRTR2ALDH1A1MAPT | |
| SCHEMBL4691406 | 0.83 | HCRTR1 (0.48) | TSHRHCRTR1HCRTR2ALDH1A1MAPT | |
| SCHEMBL4691305 | 0.83 | MAPT (0.42) | RAB9ASMN1; SMN2HSD17B10HCRTR1HCRTR2 | |
| SCHEMBL4690742 | 0.82 | HCRTR1 (0.46) | RAB9AHPGDSMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL4690670 | 0.82 | UBE2M (0.44) | RAB9ASMN1; SMN2HCRTR1HCRTR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |