Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | HTR6 | P50406 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.46 |
| ▸ | HTR3B | O95264 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL92331 | 0.84 | L3MBTL1 (0.56) | CYP2C9CYP2C19MAPTKMT2ASIGMAR1 | |
| SCHEMBL4692001 | 0.83 | MEN1 (0.47) | CYP2C9CYP2C19MAPTKMT2ASIGMAR1 | |
| Hydrochloric Acid SCHEMBL4768580 | 0.83 | L3MBTL1 (0.54) | CYP2C9CYP2C19MAPTKMT2ASIGMAR1 | |
| Bromide SCHEMBL28426487 | 0.83 | L3MBTL1 (0.54) | CYP2C9CYP2C19MAPTKMT2ASIGMAR1 | |
| SCHEMBL29452905 | 0.82 | SMN1; SMN2 (0.49) | CYP2C9CYP2C19MAPTKMT2ATDP1 | |
| SCHEMBL3154100 | 0.82 | POLB (0.67) | CYP2C9CYP2C19MAPTKMT2AHTR6 | |
| Hydrochloric Acid SCHEMBL6417883 | 0.81 | SLC6A2 (0.44) | CYP2C9CYP2C19MAPTKMT2ASLC6A4 | |
| SCHEMBL26357044 | 0.80 | MAPT (1.00) | CYP2C9CYP2C19MAPTKMT2ASIGMAR1 | |
| SCHEMBL4689238 | 0.80 | SOS1 (0.46) | CYP2C9CYP2C19MAPTHTR2AALDH1A1 | |
| SCHEMBL3906515 | 0.80 | SLC6A2 (0.47) | CYP2C9CYP2C19MAPTKMT2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539714-B1 | 8-HYDROXY-1-OXO-TETRAHYDROPYRROLOPYRAZINE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2008-08-13 | — | — | EP | disclosed |
| US-7399763-B2 | 8-hydroxy-1-oxo-tetrahydropyrrolopyrazine compounds useful as HIV integrase inhibitors | MERCK & CO., INC. (US) | 2008-07-15 | — | — | US | disclosed |
| US-7399763-B2 | 8-hydroxy-1-oxo-tetrahydropyrrolopyrazine compounds useful as HIV integrase inhibitors | MERCK & CO., INC. (US) | 2008-07-15 | — | — | US | disclosed |
| US-7399763-B2 | 8-hydroxy-1-oxo-tetrahydropyrrolopyrazine compounds useful as HIV integrase inhibitors | MERCK & CO., INC. (US) | 2008-07-15 | — | — | US | disclosed |
| EP-1539714-A4 | 8-HYDROXY-1-OXO-TETRAHYDROPYRROLOPYRAZINE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2007-04-25 | — | — | EP | disclosed |
| US-20050288293-A1 | 8-hydroxy-1-oxo-tetrahydropyrrolopyrazine compounds useful as hiv integrase inhibitors | MERCK SHARP & DOHME CORP. | 2005-12-29 | — | — | US | disclosed |
| EP-1539714-A2 | 8-HYDROXY-1-OXO-TETRAHYDROPYRROLOPYRAZINE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004047725-A2 | 8-HYDROXY-1-OXO-TETRAHYDROPYRROLOPYRAZINE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS | MERCK & CO. INC. (US) | 2004-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288293-A1 | 8-hydroxy-1-oxo-tetrahydropyrrolopyrazine compounds useful as hiv integrase inhibitors | TYMP, TOP1, REV1 | CYP2C9 543/4885CYP2C19 516/4885MAPT 3629/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.