Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 4/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 8/20 | 0.46 |
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4693098 | 0.85 | TNF (0.38) | DRD3HRH4HRH3HCRTR1 | |
| SCHEMBL4692886 | 0.83 | ALDH1A1 (0.42) | MEN1HCRTR1KMT2A | |
| SCHEMBL4693484 | 0.82 | HCRTR1 (0.48) | MEN1HCRTR1KMT2A | |
| SCHEMBL4695278 | 0.82 | CCR3 (0.43) | DRD3HRH4HRH3DRD2 | |
| SCHEMBL3281863 | 0.82 | HCRTR1 (0.48) | HCRTR1 | |
| SCHEMBL4692168 | 0.81 | HDAC6 (0.43) | DRD3DRD2MEN1HCRTR1KMT2A | |
| SCHEMBL4693800 | 0.81 | RAB9A (0.43) | SMN1; SMN2MEN1HCRTR1KMT2A | |
| SCHEMBL4695830 | 0.81 | KDM5A (0.35) | HRH4HRH3HCRTR1 | |
| SCHEMBL4691904 | 0.80 | HCRTR1 (0.46) | MEN1HCRTR1KMT2A | |
| SCHEMBL4694224 | 0.80 | TNF (0.39) | HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |