SCHEMBL469487

SCHEMBL469487

O=[N+]([O-])c1ccc(/C=N/c2ccccc2)c(O)c1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FNTA P49354 1/20 0.63
FNTB P49356 1/20 0.63
MAOB P27338 1/20 0.57
MAPT P10636 9/20 0.53
ALDH1A1 P00352 7/20 0.53
KDM4E B2RXH2 4/20 0.53
LMNA P02545 4/20 0.53
GAA P10253 2/20 0.53
HPGD P15428 2/20 0.53
RAB9A P51151 2/20 0.53
NPC1 O15118 1/20 0.53
POLB P06746 1/20 0.53
SMN1; SMN2 Q16637 4/20 0.49
HTT P42858 2/20 0.49
HCRTR1 O43613 1/20 0.49
CYP1A2 P05177 1/20 0.48
CYP3A4 P08684 1/20 0.48
CYP2D6 P10635 1/20 0.48
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14011737 0.88 FNTA (0.79) FNTAFNTBMAOBMAPTALDH1A1
SCHEMBL22611887 0.88 FNTA (0.79) FNTAFNTBMAOBMAPTALDH1A1
SCHEMBL12416775 0.83 FNTA (0.76) FNTAFNTBMAOBMAPTALDH1A1
SCHEMBL22624802 0.82 FNTA (0.46) FNTAFNTBMAOBMAPTALDH1A1
SCHEMBL12416649 0.82 SIRT2 (0.69) FNTAFNTBMAOBMAPTALDH1A1
SCHEMBL22624809 0.81 FNTA (0.76) FNTAFNTBMAOBMAPTALDH1A1
SCHEMBL22624804 0.79 FNTA (0.65) FNTAFNTBMAOBMAPTALDH1A1
SCHEMBL6742179 0.78 GPR35 (0.51) MAPTALDH1A1KDM4ELMNAGAA
SCHEMBL6742183 0.77 MAPT (0.56) MAPTALDH1A1KDM4ELMNAGAA
SCHEMBL1027159 0.77 MAPT (0.46) FNTAFNTBMAOBMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2614091-B1 CATALYST FOR POLYMERIZING NORBORNENE MONOMERS AND A METHOD FOR PRODUCING NORBORNENE POLYMER SHOWA DENKO KK (JP) 2016-04-20 EP disclosed
US-20130059993-A1 CATALYST FOR POLYMERIZATION OF NORBORNENE MONOMERS, METHOD FOR PRODUCING NORBORNENE POLYMER, METHOD FOR PRODUCING NORBORNENE COPOLYMER, NORBORNENE POLYMER AND TRANSITION METAL COMPLEX SHOWA DENKO K.K. (JP) 2013-03-07 US disclosed
US-20130059993-A1 CATALYST FOR POLYMERIZATION OF NORBORNENE MONOMERS, METHOD FOR PRODUCING NORBORNENE POLYMER, METHOD FOR PRODUCING NORBORNENE COPOLYMER, NORBORNENE POLYMER AND TRANSITION METAL COMPLEX SHOWA DENKO K.K. (JP) 2013-03-07 US disclosed
WO-2012033227-A2 CATALYST FOR POLYMERIZING NORBORNENE MONOMERS AND A METHOD FOR PRODUCING NORBORNENE POLYMER SHOWA DENKO K.K. (JP) 2012-03-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130059993-A1 CATALYST FOR POLYMERIZATION OF NORBORNENE MONOMERS, METHOD FOR PRODUCING NORBORNENE POLYMER, METHOD FOR PRODUCING NORBORNENE COPOLYMER, NORBORNENE POLYMER AND TRANSITION METAL COMPLEX NNMT, PPOX, DNMT1 FNTA 1034/4885FNTB 992/4885MAOB 886/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.