Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4696924 | 0.92 | CHRM2 (0.41) | MCHR1CHRM2ACHEBCHEHRH3 | |
| SCHEMBL4692594 | 0.90 | CHRM2 (0.42) | MCHR1CHRM2ACHEBCHEPOLB | |
| SCHEMBL4693819 | 0.88 | CHRM2 (0.42) | MCHR1CHRM2ACHEBCHEHRH3 | |
| SCHEMBL5280124 | 0.87 | CHRM2 (0.46) | MCHR1CHRM2ACHEBCHE | |
| SCHEMBL6021912 | 0.85 | CHRM2 (0.56) | CHRM2ACHEBCHE | |
| SCHEMBL4692420 | 0.83 | MCHR1 (0.38) | MCHR1CHRM2ACHEBCHEPOLB | |
| SCHEMBL4695275 | 0.82 | CHRM2 (0.35) | MCHR1CHRM2HRH3 | |
| SCHEMBL5273742 | 0.77 | NAMPT (0.35) | CHRM2LMNADRD3 | |
| SCHEMBL4693546 | 0.75 | POLB (0.40) | ACHEBCHELMNAPOLB | |
| SCHEMBL4695739 | 0.75 | AKR1C3 (0.40) | ACHEPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893577-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2008-03-05 | — | — | EP | claimed |
| WO-2006138218-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2006-12-28 | — | — | WO | claimed |