Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692679 | 0.82 | PDCD1 (0.41) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL4695739 | 0.82 | AKR1C3 (0.40) | POLBALDH1A1MEN1KMT2AGAA | |
| SCHEMBL4694658 | 0.80 | ALDH1A1 (0.36) | MCL1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL2639688 | 0.79 | POLB (0.44) | POLBALDH1A1GAABCHEACHE | |
| SCHEMBL6027362 | 0.79 | TRPV1 (0.39) | ALDH1A1LMNABCHE | |
| SCHEMBL4691194 | 0.78 | DRD4 (0.38) | ALDH1A1MEN1KMT2AGAAMAPT | |
| SCHEMBL4696924 | 0.77 | CHRM2 (0.41) | POLBLMNABCHEACHE | |
| SCHEMBL4691773 | 0.76 | KDM4E (0.41) | POLBALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL4695744 | 0.75 | HDAC1 (0.37) | POLBALDH1A1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL6027475 | 0.75 | TRPV1 (0.37) | POLBGAALMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893577-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2008-03-05 | — | — | EP | claimed |
| WO-2006138218-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2006-12-28 | — | — | WO | claimed |