SCHEMBL4695314

SCHEMBL4695314

Cc1ccc(C(CC(N)=O)N2CC3CN(C(=O)c4c(C)oc5c4CCCC5)CC3C2)cc1Cl

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 1/20 0.35
HCRTR2 O43614 1/20 0.35
CCR5 P51681 3/20 0.34
CCL5 P13501 1/20 0.34
TSHR P16473 2/20 0.33
TNF P01375 1/20 0.33
ALDH1A1 P00352 3/20 0.32
POLB P06746 2/20 0.32
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32
TACR1 P25103 1/20 0.31
TP53 P04637 1/20 0.31
MAPT P10636 3/20 0.31
GAA P10253 1/20 0.31
HSD17B10 Q99714 1/20 0.31
S1PR1 P21453 1/20 0.31
KDM4E B2RXH2 1/20 0.30
HPGD P15428 1/20 0.30
CYP2C19 P33261 1/20 0.30
LMNA P02545 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4689729 0.86 CCR5 (0.47) HCRTR1HCRTR2CCR5CCL5TSHR
SCHEMBL4694334 0.84 HCRTR1 (0.43) HCRTR1HCRTR2CCR5CCL5TNF
SCHEMBL3281863 0.84 HCRTR1 (0.48) HCRTR1HCRTR2CCR5TNF
SCHEMBL4690403 0.84 HCRTR1 (0.39) HCRTR1HCRTR2CCR5TNFALDH1A1
SCHEMBL4691534 0.82 GFER (0.43) HCRTR1HCRTR2CCR5TSHRALDH1A1
SCHEMBL4694815 0.81 HCRTR1 (0.37) HCRTR1HCRTR2CCR5CCL5TNF
SCHEMBL4694788 0.81 HCRTR1 (0.45) HCRTR1HCRTR2CCR5TNFMAPT
SCHEMBL3283594 0.81 CCL5 (0.43) CCR5CCL5
SCHEMBL4694763 0.80 HCRTR1 (0.37) HCRTR1HCRTR2CCR5TNFMAPT
SCHEMBL4692329 0.80 CCR5 (0.44) HCRTR1HCRTR2CCR5TNFALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1761542-B1 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS HOFFMANN LA ROCHE (CH) 2008-01-02 EP claimed